[Glu2]-TRH
Product Information
| Cas No. | 85541-78-2 |
| Puriy | ≥95% |
| Molucular Weight | 354 |
| Formula | C15H22N4O6 |
| Solubility in DMSO | 100mg/mL |
| InChIKey | HYZBGWLLSXSYLX-GUBZILKMSA-N |
| Sequence (Short) | {Pyr}-EP-NH2 |
| Sequence | Pyr-Glu-Pro-NH2 |
| Description | (Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS. |
| Target | Endogenous Metabolite; Thyroid Hormone Receptor |
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