[Ile76]-TNF-a (70-80) (human)
Product Information
| Cas No. | 163045-82-7 |
| Puriy | ≥95% |
| Molucular Weight | 1218 |
| Formula | C55H91N15O16 |
| Sequence (Short) | PSTHVLITHTI |
| Sequence | Pro-Ser-Thr-His-Val-Leu-Ile-Thr-His-Thr-Ile |
| Description | The peptide PSTHVLITHTI corresponds to residues 70-80 of human TNF-α substituted with Ile at position 76 and exhibits many of the biological activities found for TNF-α. (Ile⁷⁶)-TNF-α (70-80) has been shown to enhance human polymorphonuclear-mediated killing of Plasmodium falciparum in vitro and to reduce Plasmodium chabaudi parasitemia in mice. However, in vivo toxicity studies showed that (Ile⁷⁶)-TNF-α (70-80) does not possess the typical toxic effects of TNF. |
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